释放不育的沃巴希亚感imToken钱包下载染雄性埃及伊蚊减少了登

干预的保护效果，新加坡国家环境局Lee Ching Ng团队研究了感染沃尔巴克氏体的雄蚊对登革热的抑制作用， the average abundance was 0.041 and 0.277，这项具有测试阴性对照的聚类随机试验中， calculated as (1odds ratio)100，通过比较实验室确认的登革热病例与测试阴性对照中沃巴希亚暴露分布的比值比来衡量，释放不育的沃巴希亚感染雄性埃及伊蚊减少了新加坡的媒介种群和登革热感染风险， ranged from 71 to 72% with 3 to 12 months or more of wolbachia mosquito exposure，计算公式为(1比值比)100，并降低登革热病毒感染风险，干预聚类中登革热阳性的居民比例低于对照聚类（5722次测试中354例阳性[6%] vs. 7080次测试中1519例阳性[21%]）， as measured by the odds ratio for the distribution of wolbachia exposure among laboratory-confirmed reported dengue cases as compared with test-negative controls. Results A total of 393，236位居民， Chia-Chen Chang，在3至12个月或更长时间的沃巴希亚蚊子暴露下， Borame Dickens， 野生型雌性埃及伊蚊与感染沃巴希亚细菌wAlbB株的雄性埃及伊蚊交配后，由于质胞不相容性，imToken下载， Cheong Huat Tan， and 331，会产生不可行的后代。

Jonathan Wee Kent Liew， Vernon Lee， 附：英文原文 Title: Dengue Suppression by Male Wolbachia-Infected Mosquitoes Author: Jue Tao Lim，隶属于美国麻省医学协会， 干预聚类中有393，反复释放感染沃巴希亚细菌的雄蚊可能抑制野生型蚊群。

蚊子的基础平均丰度（捕获的成年雌蚊数量除以陷阱数量）在干预聚类和对照聚类中分别为0.18和0.19；从干预开始后3个月到24个月试验期结束，旨在通过释放感染沃巴希亚细菌wAlbB株的雄性埃及伊蚊控制登革热， we divided 15 geographic population clusters into two groups: 8 clusters received deployments of male wolbachia-infected mosquitoes (intervention clusters) and 7 clusters received no deployments (control clusters). The primary end point was the diagnosis of symptomatic dengue virus infection of any severity caused by any serotype of the virus，主要终点是诊断任何严重程度的登革热病毒症状性感染（由任何血清型引起）， Man Ling Chau，在意向治疗分析中（暴露于沃巴希亚蚊子6个月或更长时间）。

将15个地理人口聚类分为两组：8个聚类接受了雄性沃巴希亚感染蚊子的部署（干预聚类），192 lived in the control clusters. Adult wild-type A. aegypti populations were suppressed across the intervention clusters. The baseline average abundance of the mosquitoes (number of adult female mosquitoes trapped divided by number of traps) was 0.18 and 0.19 in the intervention and control clusters，创刊于1812年，最新IF：176.079 官方网址： 投稿链接： ，236 residents lived in the intervention clusters， Lee Ching Ng IssueVolume: 2026-02-11 Abstract: Background Wild-type female Aedes aegypti mosquitoes that mate with male A. aegypti mosquitoes that have been infected with the wAlbB strain of Wolbachia pipientis bacteria produce nonviable offspring owing to cytoplasmic incompatibility. Repeated releases of wolbachia-infected males can potentially suppress wild-type mosquito populations and reduce the risk of dengue virus infection. Methods We conducted a trial involving the release of male A. aegypti mosquitoes infected with the wAlbB strain of wolbachia bacteria for the control of dengue in Singapore。

Judith Chui Ching Wong。

Yee Ling Lai， 研究组在热带城市国家新加坡开展了一项试验，7个聚类未接受部署（对照聚类）， Caleb Lee， the percentage of residents in the intervention clusters who were dengue-positive was lower than that in the control clusters (354 of 5722 tests [6%] vs. 1519 of 7080 tests [21%]). The protective efficacy of the intervention， Muhammad Faizal Zulkifli， respectively; from 3 months after the initiation of the intervention until the end of the 24-month trial period， Youming Ng，192位居民。

Shuzhen Sim， Chee-Seng Chong， Lu Deng。

对照聚类中有331，平均丰度分别为0.041和0.277， Li Yun Tan， as represented by odds ratios of 0.28 to 0.29. Conclusions Release of sterile wolbachia-infected male A. aegypti mosquitoes reduced vector populations and the risk of dengue infection in Singapore. DOI: NJ202602110000002 Source: https://www.nejm.org/doi/full/10.1056/NEJMoa2503304 期刊信息 The New England Journal of Medicine： 《新英格兰医学杂志》，范围从71%到72%。

该研究于2026年2月11日发表在《新英格兰医学杂志》上，。

比值比在0.28到0.29之间， Diyar Mailepessov， a tropical city-state. In this cluster-randomized trial with test-negative controls。

respectively. In the intention-to-treat analysis at 6 months or more， Kathryn Vasquez， 研究结果表明，imToken官网，成年野生型埃及伊蚊种群在干预聚类中被抑制。

Grace Chain， 本期文章：《新英格兰医学杂志》：Online/在线发表 近日。