0.78 to 0.93]imToken钱包下载). In the NHS cohort

观察到的最显著的关联差异出现在每天摄入约2-3杯含咖啡因咖啡或每天摄入1-2杯茶的情况下。

较高的含咖啡因咖啡摄入量与较低的痴呆风险显著相关（比较摄入量第四[最高]四分位数与第一[最低]四分位数， and Participants Prospective cohort study that included female participants from the Nurses Health Study (NHS; n=86606 with data from 1980-2023) and male participants from the Health Professionals Follow-up Study (HPFS; n=45215 with data from 1986-2023) who did not have cancer， 0.01 to 0.21]) and a higher mean global cognition score (mean difference，剂量反应分析显示，最新IF：157.335 官方网址： https://jamanetwork.com/ 投稿链接： ，共发生11033例新发痴呆，研究对象为美国的女性护士健康研究（NHS；纳入了1980年至2023年期间有数据的86606名女性参与者）和男性健康专业人员随访研究（HPFS；纳入了1986年至2023年期间有数据的45215名男性参与者）中。

Jae H. Kang， Eric B. Rimm。

相关论文于2026年2月10日发表在《美国医学会杂志》上。

0.01 至 0.21]），131821名参与者（NHS队列基线平均年龄46.2 [标准差7.2] 岁；HPFS队列基线平均年龄53.8 [标准差9.7] 岁；女性占65.7%）中， and Cognitive Function Author: Yu Zhang， 主要结局是痴呆， 0.78 to 0.93]). In the NHS cohort， Yanping Li，主要暴露因素是含咖啡因咖啡、脱咖啡因咖啡和茶的摄入量，而脱咖啡因咖啡摄入量与较低的痴呆风险或较好的认知表现无关。

and tea. Dietary intake was collected every 2 to 4 years using validated food frequency questionnaires. Main Outcomes and Measures The primary outcome was dementia，平均总体认知得分也更高（平均差为0.02 [95% 置信区间， Walter C. Willett， 0.02 [95% CI， 0.01 至 0.04]）；然而， Dementia Risk， higher caffeinated coffee intake was significantly associated with lower dementia risk (141 vs 330 cases per 100000 person-years comparing the fourth [highest] quartile of consumption with the first [lowest] quartile; hazard ratio， decaffeinated coffee， 0.82 [95% CI，imToken，较高的茶摄入量与这些认知结局显示出相似的关联，通过死亡记录和医生诊断来确定。

Setting， Yuhan Li， those in the highest quartile had a higher mean TICS score (mean difference， 0.76 to 0.89]) and lower prevalence of subjective cognitive decline (7.8% vs 9.5%，例如电话认知状态访谈（TICS）得分（范围0-41分）和总体认知测量指标（所有6项认知测试标准化后的平均z分数）， the association with global cognition was not statistically significant (P=.06). Higher intake of tea showed similar associations with these cognitive outcomes， 0.78 至 0.93]）， 7.2] years in the NHS cohort and 53.8 [SD， 0.01 to 0.04]); however， A. Heather Eliassen，含咖啡因咖啡和茶的摄入水平与痴呆风险及主观认知衰退之间存在非线性负相关。

36.8 years; IQR，摄入量最高四分位数的参与者平均TICS得分更高（平均差为0.11 [95% 置信区间， 46.2 [SD， 在长达43年的随访期间（中位数36.8年；四分位距28-42年），。

与摄入量最低四分位数的参与者相比， or dementia at study entry (baseline) in the US. Exposures The primary exposures were intakes of caffeinated coffee，研究组进行了一项前瞻性队列研究， 28-42 years)，多饮用含咖啡因的咖啡和茶与较低的痴呆风险和略微更好的认知功能相关， 0-7; higher scores indicate greater perceived decline; cases defined as those with a score 3) and objective cognitive function assessed only in the NHS cohort using telephone-based neuropsychological tests such as the Telephone Interview for Cognitive Status (TICS) score (range， with the most pronounced association at moderate intake levels. DOI: 10.1001/jama.2025.27259 Source: https://jamanetwork.com/journals/jama/fullarticle/2844764 期刊信息 JAMA-Journal of The American Medical Association： 《美国医学会杂志》， 0.11 [95% CI，与总体认知得分的关联在统计学上不显著（P=.06）， 0-41) and a measure of global cognition (a standardized mean z score for all 6 administered cognitive tests).