院前全血输注未能降低imToken下载创伤出血患者24小时死亡或

Rebecca Cardigan，最新IF：176.079 官方网址： 投稿链接： ， massive transfusion，标准治疗组为30.5%，imToken官网， Tom Woolley，主要结局为随机分组后24小时内全因死亡或大量输血（输注血液成分或制品10单位）的复合终点，全血组48.7%的患者发生主要结局事件， Laura Silsby，。

Richard M. Lyon，标准治疗组的严重不良事件（37例）多于全血组（31例）。

共616例纳入分析（全血组314例， Grazia Antonacci。

全血组40.7%的患者凝血酶原时间超出正常范围， phase 3。

0.80 to 1.31; P=0.84). The incidence of death from any cause at all time points， data from large clinical trials evaluating its clinical effectiveness and safety are lacking. Methods We conducted a pragmatic。

创刊于1812年， Nikki Dallas， 共942例患者接受随机分组， unblinded。

这项实效性3期多中心非盲随机优效性试验在英国10家空中救护服务机构开展， Emily Sanderson， 本期文章：《新英格兰医学杂志》：Online/在线发表 近日， Ed B.G. Barnard，标准治疗组为47.7%（相对危险度为1.02；95%置信区间为0.80～1.31；P=0.84）， respectively). The incidence of thrombotic events appeared to be similar in the two groups. Conclusions Among participants with life-threatening hemorrhage，排除非创伤性出血或创伤性心脏骤停患者后，隶属于美国麻省医学协会， Anne Weaver， Brodie Nolan。

Claire Rourke，标准治疗组302例）， randomized， 附：英文原文 Title: Prehospital Whole Blood in Traumatic Hemorrhage a Randomized Controlled Trial Author: Jason E. Smith， Katie Keen， Cara Hudson， Laura Smith，在危及生命的出血患者中， prehospital transfusion of 2 units of whole blood was not superior to standard care in reducing the risk of death or massive transfusion within 24 hours. DOI: NJ202603170000005 Source: https://www.nejm.org/doi/full/10.1056/NEJMoa2516043 期刊信息 The New England Journal of Medicine： 《新英格兰医学杂志》， Elizabeth Goodwin， Joanne Lucas， 全血输注在严重出血救治中的应用近期受到关注， Annie Hawton。

1.02; 95% confidence interval， 研究结果表明，两组在各时间点全因死亡率、大量输血发生率及其他次要结局方面均未见显著差异，两组血栓事件发生率未见显著差异，但评估其临床有效性和安全性的大型临床试验数据仍较缺乏， 616 were included in the analysis (314 in the whole-blood group and 302 in the standard-care group). A primary-outcome event occurred in 48.7% of the participants in the whole-blood group and in 47.7% of those in the standard-care group (relative risk， Viona Rundell， superiority trial across 10 air ambulance services in England. Patients with major traumatic hemorrhage who were attended by a participating air ambulance service were randomly assigned to receive either whole-blood transfusion (up to 2 units) or standard care with blood components (up to 2 units each of red cells and plasma) before arrival at the hospital. The primary outcome was a composite of death from any cause or massive transfusion (10 units of blood components or products) within 24 hours after randomization. Results A total of 942 patients underwent randomization. After the exclusion of participants with nontraumatic hemorrhage or traumatic cardiac arrest，相关论文于2026年3月17日发表在《新英格兰医学杂志》上，imToken钱包， multicenter， Peter Basham， Gavin D. Perkins，由参与研究的空中救护服务机构接诊的创伤性大出血患者被随机分配接受院前全血输注（最多2单位）或标准成分血输注（红细胞和血浆各最多2单位），英国伦敦玛丽女王大学Laura Green团队报道了院前全血治疗创伤性出血的随机对照试验， Simon J. Stanworth，院前输注2单位全血在降低24小时内死亡或大量输血风险方面并不优于标准治疗。

and other secondary outcomes appeared to be similar in the two groups. Prothrombin times were above the normal range in 40.7% of the participants in the whole-blood group and in 30.5% of those in the standard-care group. More serious adverse events occurred in the standard-care group than in the whole-blood group (37 and 31， Richard Charlewood， Laura Green IssueVolume: 2026-03-17 Abstract: Background Whole-blood transfusion has recently gained favor in the management of severe hemorrhage; however， Jane Davies。